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Time Out saysThe first US picture from the Mexican director of Cronos is a sci-fi thriller, fusing a dark, poetic allegory about the perils of genetic manipulation with grim, relentless, subterranean horror. Three years after scientists Sorvino and Northam save New York's children from a polio-like epidemic - by tampering with the DNA structure of the disease's main carrier, the ubiquitous cockroach - the results of their arrogant experiments come back to haunt them. Giant fast-evolving insects now lurk in the subway tunnels beneath the city, mimicking and preying upon their sometime predators, human beings. Uncompromising, subversive and occasionally perversely comic.