Delicatessen The long-awaited sequel to Chelsea’s Cafeteria opens this week in Soho. Chef Doron Wong (Park Avenue Café) sticks to the comfort-food formula with dishes both highbrow (lamb chops with couscous and fennel jam) and low (cheeseburger spring rolls). The “deli” aspect of the menu is subtle, but you will find pastrami and matzo ball soup at this haute greasy spoon. 54 Prince St at Lafayette St (212-226-0211)

Five Guys Burgers and Fries Because Slope dwellers can’t live by the Coop alone, the Brooklyn nabe has welcomed an outpost of this Eat Out Award–winning burger chain. The brand’s signature lineup of hand-molded patties and house-cut fries will be offered. 284 Seventh Ave between 6th and 7th Sts, Park Slope, Brooklyn (718-499-9380)

Fresco by Scotto on the Go The downtown outpost of midtown’s casual Italian lunch spot occupies a staggering 8,500 square feet. 114 Pearl St at Hanover Sq (212-635-5000). Subway: 2, 3 to Wall St; 4, 5 to Bowling Green. Mon–Fri 6:30am–9pm. Average main course: $9.

Indian Road Café Thirty windows provide Hudson River views at Inwood’s new three-level eatery. Co-owner Jason Minter furnished the spot with tables and chairs plucked from the set of The Sopranos, where he worked as an associate producer. French-press coffee and an eclectic wine list spanning “Johannesburg to Dallas” are offered, along with casual fare like a panino stuffed with prosciutto, fig jam, Manchego cheese and arugula. 600 W 218th St at Indian Rd (212-942-7451)

I Vandali The name, which translates to “the vandals,” refers to this Italian spot’s key gimmick—guests are invited to scribble on white panels that hang from the exposed-brick walls. Contemplate your crayon legacy over affordable small plates from chef Marco Sanmartino (Cento Lire) like crostini with lardo butter and white-bean puree; larger dishes include a grilled pork chop with baked applesauce. 1590 First Ave between 82nd and 83rd Sts (212-585-3339)

James First-time restaurateurs Deborah Williamson and Bryan Calvert are behind this elegant brownstone cafe in Prospect Heights. Calvert (Union Pacific) turns out dishes like crab-stuffed zucchini blossoms. 605 Carlton Ave at St. Marks Ave, Prospect Heights, Brooklyn (718-942-4255)

Kurve Chef and owner Andy Wang (Rhong Tiam) opens this Pan-Asian spot, featuring desserts by Pichet Ong (P*ong). 87 Second Ave at 5th St (212-260-8018). Subway: 6 to Astor Pl. Dinner. Average main course: $20.

Macondo Chef and co-owner Máximo Tejada (Rayuela) claimed the former LoSide space to open this paean to Latin-American street food. Venezuelan arepas are offered with toppings like oven-roasted quail; empanadas can be stuffed with shrimp or vegetables; and tacos feature fillings like lamb. Mixologist Junior Merino mans the hooch. 157 E Houston St between Allen and Eldridge Sts (212-254-2080)

Matsugen Jean-Georges Vongerichten teams with Japanese restaurateurs (and brothers) Yoshiharu, Takayuki and Masashi Matsushita to open this soba-focused eatery in the former 66 space. Hand-rolled buckwheat noodles from chef Choji Miyano are the principal draw (try a hot version served with giant prawns in bonito broth), but sushi and shabu-shabu are also available.
241 Church St between Leonard and Worth Sts (212-925-0202)

Peaches Smoke Joint owners Craig Samuel and Ben Grossman reprise their all-American formula at this regional café. The Southern-inflected Greenmarket menu is a salve for restaurant-parched Bedford-Stuyvesant: Try lightly fried seasonal vegetables dressed in a lemon-pepper sauce, or cornmeal-crusted trout with black-eyed pea succotash. 393 Lewis Ave between Decatur and MacDonough Sts, Bedford-Stuyvesant, Brooklyn (718-942-4162)

Socarrat Paella Bar This slim Spanish eatery, beautified by Allen & Delancey designers Jason Volenec and Silvia Zofio, opens this week in Chelsea. Chef Felipe Camarillo (Suba) focuses on paella. Sample six varieties (one features chicken, chorizo and pork loin) and mine the (forthcoming) list of Iberian beers and wines at the 20-seat communal table. 259 W 19th St between Seventh and Eighth Aves (212-462-1000)

Uncle Nick’s This spin-off of the Times Square Greek eatery features balcony seating and classic taverna decor. 382 Eighth Ave at 29th St (212-609-0500). Subway: 1 to 28th St. Lunch, dinner. Average main course: $15.

Vai Chef-owner Vincent Chirico (Tocqueville) launches an Italian small-plates destination uptown. 225 W 77th St between Broadway and Amsterdam Ave (212-362-4500). Subway: 1 to 79th St. Dinner. Average main course: $20.

Zemi Owner Mary Hwang-Zheng (Vynl) channels a fusion of Asian and American comfort foods at this West Side eatery. Dishes like hot-and-spicy-beef and crab rangoon dumplings are offered along side a three-cheese mac. Signature cocktails tend toward the kitschy: see the Blue Dragon (blueberry vodka with muddled berries, lemonade and blue curaçao). 130 Ninth Ave at 18th St (212-924-6950)

Food & drink shops

Lia’s Ices Look out, Louie G’s. Another walk-up ice-creamery opens in southern Brooklyn. 471 16th St at Prospect Park West, Windsor Terrace, Brooklyn (718-864-3282). Subway: F to 15th St–Prospect Park. Mon–Thu, Sun 11am–11pm; Fri, Sat 11am–midnight. Average ice: $3.

Tabla Street Cart Chef Floyd Cardoz offers frankies and rotis at this curbside, lunch-only pushcart. 11 Madison Ave at 25th St (no phone). Subway: N, R, W, 6 to 23rd St. Mon–Fri 11:30am–3pm. Average item: $7.

Whole Foods Market A fifth NYC location of the organic superstore—this one inhabiting a mind-blowing 69,000 square feet—opens this week in Tribeca. Joining the market’s retail lineup is an oyster- and clam-shucking station and a shawarma spit. 270 Greenwich St at Warren St (212-349-6555)