Art and fashion go together like Miley Cyrus and twerking (these days, at least). For Lower East Side Opening Night, more than 40 galleries will unveil their fall shows amid a giant block party and a “Looks of the Lower East Side” fashion show (6:30pm). Boutiques—including Quinn, Epaulet and Urban Cricket—will be hawking their wares to well-dressed revelers, while DJs and bands (such as punkers Countdown Love) liven up an outdoor stage. Orchard St between Broome and Grand Sts.