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As the city's premier artistic hub, the 450 Harrison building is a veritable hive of artistic activity in the back of the South End. Many artists open their doors a few times a month for open studios events where they greet locals and visitors. First Fridays is the flagship event; held each month, more than 200 artists, galleries, shops and showrooms welcome everyone from art aficionados to afterwork activity-seekers for an evening of art, wine, cheese and mingling.