What’s a tell-tale sign that a neighborhood is on the up? It gets its first new hotel in more than a decade. Mr. C isn’t just new to the state (it’s the Cipriani brothers’ first property in Florida), it’s also a fresh and welcomed addition to Coconut Grove, which is in the throes of a renaissance. The nautical-themed, midcentury-inspired accommodations comprise 100 guest rooms and suites, plus a rooftop pool that overlooks Biscayne Bay and is adjacent to lovely indoor/outdoor bar and restaurant Bellini. Down below at ground level, guests will find lush courtyard Il Giardino for all their al fresco drinking needs, and free bike rentals should they feel inclined to take a quick spin around the waterfront neighborhood.