DNA Lounge

Longtime DNA owner Jamie Zawinski is a former dot-com software engineer-turned-nightlife legend. His sprawling SoMa lounge spans two stages, seven bars, and four dance floors. The eclectic line-up offers something for every niche, whether it’s burlesque dancers, live bands, or the goth-industrial Death Guild. But DNA is best known for the infamous Bootie SF, which has since expanded to L.A. and beyond. Originally introduced by DJs Adrian A and Mysterious D in 2003, the long-running dance party mashes up hits from the past and present: Think Britney vs. Taylor or Gen X vs. Millennials. You can reserve 6- or 12-person booths throughout the venue for soaking up the scene between sets.