Serpentine is classic Dogpatch: artsy and industrial-cool. Though the beloved neighborhood spot underwent a renovation in 2017, the dining room is largely unchanged, recognizable by the same polished concrete bar, exposed brick walls, and soaring ceiling. The best seats in the house are the roomy leather booths up front; request one in advance. The fare is elevated American, including handmade pasta, grilled fish, oysters, and a standout fried chicken.
2495 Third Street
|Cross street:||at 22nd St|
|Opening hours:||Mon–Wed 5–10pm, Thu 10am–2:30pm, 5–10pm, Fri–Sat 10am–2:30pm, 5–11pm, Sun 10am–2:30pm|