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Sure you could stay at the Hyatt or the Hilton, but some of the best hotels in San Fran are boutique or historic locations. Whether you're visiting, hosting family or booking a staycation, there's something suitable in every neighborhood and price range. Book something downtown to be near the best attractions, or the North Beach neighborhood to be near touristy Fisherman's Wharf. Either way, try to check off the best things to do in the city from a comfy base at one of the best hotels in San Francisco.