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This well-known chain’s location at the Trump Building in the Financial District is not your average drugstore. The 22,000-square-foot, two-story food-and-beauty emporium offers impressive amenities such as a sushi bar with an in-shop chef, an expanded organic-produce section and even a machine that dispenses 130 varieties of Coca-Cola fountain drinks. Beauty mavens can head to the Sephora-rivaling Look Boutique to undergo virtual makeovers, during which a monitor snaps your picture and a computer touch screen allows you to apply shades of L’Oréal and Maybelline cosmetics digitally to your skin, eyes and lips. A complimentary automatic fragrance sampler spritzes your wrists with one of more than 40 scents, including Vera Wang Rock Princess ($60), Burberry Touch ($50) and Dolce & Gabbana the One Gentleman ($57). Visit an on-hand hairstylist for a free mane-and-scalp analysis or blowout ($35–$45) using Phyto products ($24–$60). Then head over to the nail salon for a manicure using Essie or OPI nail polishes ($10–$15), or a Shellac gel-nail polish job that lasts up to two weeks ($35). Investment bankers can pop by the retro, mahogany shoeshine stand to score an old-fashioned polish ($3); 100 percent of the proceeds benefit local charities, such as City Harvest, AIDS Walk and Susan G. Komen for the Cure. Did we also mention this Duane Reade is open 24 hours a day? Rejoice, party peeps.