Opened in 1907 as the American Seaman’s Friend Society Sailors Home, the 14-story landmark was a residential hotel when hoteliers Eric Goode and Sean MacPherson, of the Bowery and the Maritime, took it over (some long-term residents remain). The wood-paneled, 50-square-foot rooms were inspired by vintage train sleeper compartments—there’s a single bed with built-in storage and brass hooks for hanging up your clothes, but also iPod docks and wall-mounted 23-inch flat-screen TVs. If entering the hotel feels like stepping on to a film set, there’s good reason: Inspiration came from various celluloid sources, including Barton Fink’s Hotel Earle for the lobby. The "ballroom," decorated with mismatched chairs, oriental rugs and a fireplace topped with a stuffed ram, evokes an eccentric mansion. Rooms: 208.