With the economy still in the doldrums, nonprofits need more support than ever. Raise funds for the National MS Society, which is helping to find the cause and a cure for multiple sclerosis, on this annual ride. Three routes are offered, the shortest being a 30-mile jaunt around Manhattan. Opt for the 50- or 100-mile rides, and you'll haul ass under the Hudson River through the Holland Tunnel before taking a scenic, traffic-free path that winds through New Jersey and upstate New York; you'll ride back into the city by way of the George Washington Bridge. Reservations required.