If you haven't yet, you really owe it to yourself to visit this megagallery on the Bowery. Although the space has been a longtime fixture on New York's art scene, it's a recent arrival to the LES, having moved to its Lord Norman Foster–designed building just last fall. The edifice itself is a work of art, featuring a ginormous elevator that doubles as a moving gallery space, but it would be a mistake to overlook Sperone's blue-chip roster of artists, including Malcom Morley, Bruce Nauman and William Wegman. Taking up space through March 26: Evan Penny, whose hyperrealistic busts are distorted as if viewed in a fun-house mirror; and Emil Lukas, whose allover abstractions are often created in unorthodox ways—by using, for instance, insect larvae, which wriggle through paint and ink to create sinuous patterns of lines. 257 Bowery between E Houston and Stanton Sts (212-999-7337, speronewestwater.com). Tue–Sat 10am–6pm.