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What makes an artist great? It takes talent, of course, and a genius for innovation. Also, having some sort of vision helps. But a truly great artist is distinguished by a unique ability to take his or her moment in time and distill its essence so that resulting work becomes timeless. Limited to dress and hairstyle, for example, the Mona Lisa is just a woman from the Renaissance. But her expression—subtle, ambiguous—has given her a mystique that will survive the ages. And so it goes, not only for her creator, Leonardo Da Vinci, but also for the other artists (many of them included in New York museums such as The Met, MoMA and the Guggenheim) on our list of the most famous artists of all time.