Built in 1923, the Biltmore retains the Italian-Spanish renaissance elegance that once enticed such dignitaries as Winston Churchill and JFK. The ground level is striking, with one gorgeous room after another peeling off the exquisite lobby. A number of them, such as the Crystal Ballroom and the Gold Room, are available only for private hire, but if there's no event being staged and you ask nicely at reception, someone will show you around. Next to such extravagance, the rooms can hardly compete, but they're comfortable in an old-fashioned way.
Where is it? South Grand Avenue in the Financial District.
Which room? Music Suite. A two-bed, two-bath home away from home for any musician, with a baby grand in the living room, a reception area and a butler's pantry. Woah.
Time Out tip: Spend an afternoon in Pershing Square, a Spanish-inspired plaza, featuring large geometric structures painted in bright hues, and host to regular live performances.